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2. Medroxyprogesterone acetate - Wikipedia

   en.wikipedia.org/wiki/Medroxyprogesterone_acetate

   More serious side effects include bone loss, blood clots, allergic reactions, and liver problems. [10] Use is not recommended during pregnancy as it may harm the baby . [ 10 ] MPA is an artificial progestogen , and as such activates the progesterone receptor , the biological target of progesterone . [ 4 ]

3. Medroxyprogesterone - Wikipedia

   en.wikipedia.org/wiki/Medroxyprogesterone

   Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [2] [3] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position.

4. Pharmacokinetics of progesterone - Wikipedia

   en.wikipedia.org/wiki/Pharmacokinetics_of...

   Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...

5. Progesterone (medication) - Wikipedia

   en.wikipedia.org/wiki/Progesterone_(medication)

   If progesterone is taken by mouth or at high doses, certain central side effects including sedation, sleepiness, and cognitive impairment can also occur. [ 28 ] [ 20 ] The medication is a naturally occurring progestogen and hence is an agonist of the progesterone receptor (PR), the biological target of progestogens like endogenous progesterone ...

6. Hormone replacement therapy - Wikipedia

   en.wikipedia.org/wiki/Hormone_replacement_therapy

   More recently developed forms of drug delivery are alleged to have increased local effect lower dosing, fewer side effects, and constant rather than cyclical serum hormone levels. [1] [2] Transdermal and vaginal estrogen, in particular, avoid first pass metabolism through the liver. This in turn prevents an increase in clotting factors and ...

7. Estradiol cypionate/medroxyprogesterone acetate - Wikipedia

   en.wikipedia.org/.../medroxyprogesterone_acetate

   Estradiol cypionate/medroxyprogesterone acetate (EC/MPA), sold under the brand name Cyclofem among others, is a form of combined injectable birth control. [2] It contains estradiol cypionate (EC), an estrogen, and medroxyprogesterone acetate (MPA), a progestin. [2]

8. Estradiol (medication) - Wikipedia

   en.wikipedia.org/wiki/Estradiol_(medication)

   As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.

9. Progestogen (medication) - Wikipedia

   en.wikipedia.org/wiki/Progestogen_(medication)

   [92] [122] However, oral progesterone achieves very low progesterone levels and has relatively weak progestogenic effects, which might be responsible for the absence of increase in VTE risk. [122] Parenteral progesterone, such as vaginal or injectable progesterone, which can achieve luteal-phase levels of progesterone and associated ...