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  2. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. [ 1 ] Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 2 ]

  3. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    The original monoamine hypothesis postulates that depression is caused by a deficiency or imbalances in the monoamine neurotransmitters (5-HT, NE, and DA). This has been the central topic of depression research for approximately the last 50 years; [ 12 ] [ 198 ] it has since evolved into the notion that depression arises through alterations in ...

  4. Kindling (sedative–hypnotic withdrawal) - Wikipedia

    en.wikipedia.org/wiki/Kindling_(sedative...

    The mechanism of alcohol-related psychosis is due to distortions to neuronal membranes, gene expression, as well as thiamine deficiency. It is possible in some cases that alcohol abuse via a kindling mechanism can cause the development of a chronic substance-induced psychotic disorder (e.g., schizophrenia).

  5. Dopamine dysregulation syndrome - Wikipedia

    en.wikipedia.org/wiki/Dopamine_dysregulation...

    Dopamine dysregulation syndrome (DDS) is a dysfunction of the reward system observed in some individuals taking dopaminergic medications for an extended length of time. It is characterized by severely disinhibited patterns of behavior, [1] leading to problems such as addiction to the offending medication, gambling addiction, or compulsive sexual behavior, [2] along with a general orientation ...

  6. Depression is likely not caused by a chemical imbalance in ...

    www.aol.com/depression-likely-not-caused...

    For years, a chemical imbalance of serotonin has been widely viewed as the culprit for depression, resulting in the widespread use of antidepressants. The study published this week in the journal…

  7. Pharmacology of antidepressants - Wikipedia

    en.wikipedia.org/wiki/Pharmacology_of...

    The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]

  8. Long-term depression - Wikipedia

    en.wikipedia.org/wiki/Long-term_depression

    In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.

  9. Depression (mood) - Wikipedia

    en.wikipedia.org/wiki/Depression_(mood)

    Researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [90]

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