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[1] [40] [41] Addison's can affect persons of any age, sex, or ethnicity, but it typically presents in adults between 30 and 50 years of age. [41] [42] Research has shown no significant predispositions based on ethnicity. [40] About 70% of Addison's disease diagnoses occur due to autoimmune reactions, which cause damage to the adrenal cortex. [5]
A skin biopsy may be needed in unusual cases. If no clear cause is obvious, it may be necessary to search for one. Blood tests, an endoscopy, or X-rays may be required to eliminate the possibility of diabetes or cancer as the cause. [6]: 87 On biopsy, hyperkeratosis, epidermal folding, leukocyte infiltration, and melanocyte proliferation may be ...
Most people with primary Addison's disease have darkening (hyperpigmentation) of the skin, including areas not exposed to the sun; characteristic sites are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa), new scars become hyperpigmented, whereas older ones do not darken.
"Hyperpigmentation just means darkening of the skin," says Dr. Dowling. "So basically, 'hyperpigmentation' is an umbrella term for lots of different conditions that cause hyperpigmentation ...
Addison’s disease is an autoimmune condition — affecting about one in 100,000 people — in which the body attacks its organs, specifically the adrenal glands. It’s also called primary ...
Addison's disease can be caused by a variety of pathological processes. It is an endocrinal disorder where there is an increased amount of adrenocorticotropic hormone (ACTH) as a result of deficient amounts of hormones being produced from the adrenal cortex. [9] Due to this, dark pigmentation may be visible on the oral mucosa or skin. [10]
Nelson's syndrome is a disorder that occurs in about one in four patients who have had both adrenal glands removed to treat Cushing's disease. [1] In patients with pre-existing adrenocorticotropic hormone ()-secreting pituitary adenomas, loss of adrenal feedback following bilateral adrenalectomy can trigger the rapid growth of the tumor, leading to visual symptoms (e.g. bitemporal hemianopsia ...
“Cancer can be extremely defeating,” she says. “Focus on what you can control instead of what's out of your hands. It’s important to not hyper fixate on the negatives."