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[1] [40] [41] Addison's can affect persons of any age, sex, or ethnicity, but it typically presents in adults between 30 and 50 years of age. [41] [42] Research has shown no significant predispositions based on ethnicity. [40] About 70% of Addison's disease diagnoses occur due to autoimmune reactions, which cause damage to the adrenal cortex. [5]
A skin biopsy may be needed in unusual cases. If no clear cause is obvious, it may be necessary to search for one. Blood tests, an endoscopy, or X-rays may be required to eliminate the possibility of diabetes or cancer as the cause. [6]: 87 On biopsy, hyperkeratosis, epidermal folding, leukocyte infiltration, and melanocyte proliferation may be ...
Addison's disease can be caused by a variety of pathological processes. It is an endocrinal disorder where there is an increased amount of adrenocorticotropic hormone (ACTH) as a result of deficient amounts of hormones being produced from the adrenal cortex. [9] Due to this, dark pigmentation may be visible on the oral mucosa or skin. [10]
Addison’s disease is an autoimmune condition — affecting about one in 100,000 people — in which the body attacks its organs, specifically the adrenal glands. It’s also called primary ...
Most people with primary Addison's disease have darkening (hyperpigmentation) of the skin, including areas not exposed to the sun; characteristic sites are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa), new scars become hyperpigmented, whereas older ones do not darken.
Primary hyperaldosteronism has a number of causes. About 33% of cases are due to an adrenal adenoma that produces aldosterone, and 66% of cases are due to an enlargement of both adrenal glands. [1] Other uncommon causes include adrenal cancer and an inherited disorder called familial hyperaldosteronism. [6]
Related: Teen Who Beat Cancer Saves Boy, 3, Struggling with Disease in Ukraine: 'Now We're Like Family' (Exclusive) Rowan was diagnosed with alveolar soft part sarcoma, a very rare, slow-growing ...
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