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Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters:
Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.[1]
Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds.
By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction.
Acetylcholinesterase (AChE) is a serine protease degrades acetylcholine between cholinergic synapses and terminates cholinergic neural signaling (Silman and Sussman 2008). Studies have revealed that AChE activity was reduced in PD patients with cognitive impairment, and the loss of cholinergic was observed within the central and peripheral ...
Inhibition of acetylcholinesterase occurs by several distinct mechanisms. Some AChE inhibitors are useful therapeutically, whereas others have proven useful as insecticides. Still others have been manufactured for a more insidious use in chemical warfare.
Acetylcholinesterase is a serine hydrolase that cleaves choline esters rapidly, preferentially acetylcholine (ACh). AChE shows a great ACh-hydrolyzing capacity, and in the list of enzymes classified according to their catalytic efficiency AChE occupies the second position.
Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline.
The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus of intense research for much of the past century.
Abstract. By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction.