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These subepithelial infiltrates are a hallmark sign of EKC. Click image to enlarge. How it All Begins. Corneal infiltrates represent an immune response to corneal insult, whether from a microbial antigen, contact lens wear or even corneal surgery.
Most often, sterile infiltrates have been found to be located in the peripheral cornea, often within 4mm of the limbus; they are often subepithelial or anterior stromal in depth. 7,8 Sterile infiltrates tend to be nonprogressive and/or self-limiting, responsive to therapy and often do not result in serious sequelae such as an impact on visual ...
The infiltrates are thought to arise from antigen-antibody interaction resulting from viral proliferation in the overlying epithelium. Corneal stromal involvement can present as early as the second week of disease, occurring in approximately 25 percent of patients with HZO.
A corneal infiltrate is a single or group of inflammatory cells in the normally clear cornea. An infiltrate results from an infection, decreased oxygen supply or injury to the cornea. A corneal infiltrate is visible under high magnification as round, gray spots surrounded by areas of swelling. Causes of corneal infiltrates.
After this period, subepithelial infiltrates (also known as “nummuli”), which are thought to be related to the immune response, can form beneath the lesions. These occur at approximately day 10 and can give rise to irregular astigmatism and photophobia.
Corneal sub-epithelial infiltrates are a common sequel of adenoviral conjunctivitis, a highly contagious form of viral conjunctivitis that has a tendency to occur in epidemics. 1 The incidence of SEIs in patients of acute adenoviral kerato-conjunctivitis have been reported to vary from 49.1 to 80%. 2, 3 The hypothesis given is that of ...
Epidemic keratoconjunctivitis (EKC) is the most severe ocular manifestation of HAdV infection, in which the presence of subepithelial infiltrates (SEIs) in the cornea is a hallmark feature of corneal involvement. SEIs have the tendency to recur and may lead to long-term visual disability.