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The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR associated nucleases) system was originally discovered to be an acquired immune response mechanism used by archaea and bacteria. It has since been adopted for use as a tool in the genetic engineering of higher organisms.
Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and open up specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within living organisms.
The CRISPR-Cas12a system consist of a Cas12a enzyme and a guide RNA that finds and positions the complex at the correct spot on the double helix to cleave target DNA. CRISPR-Cas12a systems activity has three stages: [3] Adaptation: Cas1 and Cas2 proteins facilitate the adaptation of small fragments of DNA into the CRISPR array.
The first documented computer architecture was in the correspondence between Charles Babbage and Ada Lovelace, describing the analytical engine.While building the computer Z1 in 1936, Konrad Zuse described in two patent applications for his future projects that machine instructions could be stored in the same storage used for data, i.e., the stored-program concept.
History of Computer Software; CPU design, a technical discussion of computing history; History of operating systems; History of the Internet; History of the graphical user interface; Timeline of programming languages; Hardware description language; Hardware abstraction layer; Computer architecture, how computers are designed; List of fictional ...
CRISPR gene editing (CRISPR, pronounced / ˈ k r ɪ s p ə r / (crisper), refers to a clustered regularly interspaced short palindromic repeats") is a genetic engineering technique in molecular biology by which the genomes of living organisms may be modified.
In 1946, a model for computer architecture was introduced and became known as Von Neumann architecture. Since 1950, the von Neumann model provided uniformity in subsequent computer designs. The von Neumann architecture was considered innovative as it introduced an idea of allowing machine instructions and data to share memory space. [64]
Human Nature is a film documentary which presents an in-depth description of the gene editing process of CRISPR, and its possible implications.The film includes the perspective of the scientists who invented the process, and of the genetic engineers who are applying the process.