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A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component. [1] [2] [3] It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or ...
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.. In the past, derivative also meant a compound that can be imagined to arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, [1] but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity.
5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analogue which is incorporated into the DNA of dividing cells. EdU is used to assay DNA synthesis in cell culture and detect cells in embryonic, neonatal and adult animals which have undergone DNA synthesis. [ 1 ]
To design a transition state analogue, the pivotal step is the determination of transition state structure of substrate on the specific enzyme of interest with experimental method, for example, kinetic isotope effect. In addition, the transition state structure can also be predicted with computational approaches as a complementary to KIE.
The effect of the substrate analog can be nullified by increasing the concentration of the originally intended substrate. [6] There are also substrate analogs that bind to the binding site of an enzyme irreversibly. If this is the case, the substrate analog is called an inhibitory substrate analog, a suicide substrate, or a Trojan horse ...
The depth of analysis depends on the field of study or the chemical and physical properties of interest. The English word "isomer" ( / ˈ aɪ s əm ər / ) is a back-formation from "isomeric", [ 2 ] which was borrowed through German isomerisch [ 3 ] from Swedish isomerisk ; which in turn was coined from Greek ἰσόμερoς isómeros , with ...
Functional analogs are not necessarily structural analogs with a similar chemical structure. [1] An example of pharmacological functional analogs are morphine , heroin and fentanyl , which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.
Homologous series, a series of organic compounds having different quantities of a repeated unit; Homologous temperature, the temperature of a material as a fraction of its absolute melting point; Homologation reaction, a chemical reaction which produces the next logical member of a homologous series