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Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria. [3] Streptomycin is the first-in-class aminoglycoside antibiotic.
Ribostamycin, along with other aminoglycosides with the DOS subunit, is an important broad-spectrum antibiotic with important use against human immunodeficiency virus [citation needed] and is considered a critically important antimicrobial by the World Health Organization., [3] [4] Resistance against aminoglycoside antibiotics, such as ...
Cross-resistance can take place between compounds that are chemically similar, like antibiotics within similar and different classes. [9] That said, structural similarity is a weak predictor of antibiotic resistance, and does not predict antibiotic resistance at all when aminoglycosides are disregarded in the comparison. [10]
Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. [2] However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted ...
Streptothricins are a group of antibiotics in the aminoglycoside class. [1] The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942. [ 2 ] It was later determined to be a mixture of closely-related compounds, and is now known as nourseothricin .
Macrolides, [8] clindamycin [12] and aminoglycosides [7] (with all these three having other potential mechanisms of action as well), have evidence of inhibition of ribosomal translocation. Fusidic acid prevents the turnover of elongation factor G from the ribosome.
In enzymology, an aminoglycoside N6'-acetyltransferase (EC 2.3.1.82) is an enzyme that catalyzes the chemical reaction. acetyl-CoA + kanamycin-B CoA + N 6 '-acetylkanamycin-B. Thus, the two substrates of this enzyme are acetyl-CoA and kanamycin B, whereas its two products are CoA and N6'-acetylkanamycin-B.
The aminocyclitol family of natural products is a class of sugar-derived microbial secondary metabolites that demonstrate significant biological activities. Aminocyclitols are found as a component of aminoglycoside antibiotics which is also called as pseudosugars or pseudosaccharides.