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Some unwanted isomers are formed during irradiation: these are removed by various techniques, leaving a resin which melts at about room temperature and usually has a potency of 25 000 000 to 30 000 000 International Units/gram. Cholecalciferol is also produced industrially for use in vitamin supplements from lichens, which is suitable for ...
Alfacalcidol (or 1-hydroxycholecalciferol) is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive. Alfacalcidol has a weaker impact on calcium metabolism [ 3 ] and parathyroid hormone levels [ 4 ] than calcitriol ; but significant effects on the immune system , including regulatory T cells . [ 5 ]
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
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Elements like heat, humidity, light, and air are the “main enemies of vitamin freshness,” says Blatner. “Keep them cool, dry, and out of the sun.” So, probably not in your medicine cabinet.
It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well for osteoporosis in combination with other medications. [1] [2] In 2022, the combination, calcium/vitamin D was the 246th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [3] [4]
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