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The HGDP-CEPH Human Genome Diversity Cell Line Panel is a resource of 1,063 cultured lymphoblastoid cell lines (LCLs) from 1,050 individuals in 52 world populations, banked at the Fondation Jean Dausset-CEPH in Paris. The HGDP is not related to the Human Genome Project (HGP) and has attempted to maintain a distinct identity. [4]
Lymphoblastoid cell lines established from blood samples of humans who were centenarians (100 years old or older) have significantly higher PARP activity than cell lines from younger (20 to 70 years old) individuals, [13] again indicating a linkage between longevity and repair capability.
The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells." [4] Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.
The JY cell line is an Epstein–Barr virus (EBV)-immortalised B cell lymphoblastoid line. JY cells express HLA class-I A2 and class-II DR. JY is a suspension cell line, although the cells are known to grow in clumps. The growth medium is RPMI 1640, 10% fetal calf serum and 1% L-glutamine. [1] JY cells are positive for murine leukemia virus. [2]
Tissue culture flasks. RPMI 1640, simply known as RPMI medium, is a cell culture medium commonly used to culture mammalian cells. [1] RPMI 1640 was developed by George E. Moore, Robert E. Gerner, and H. Addison Franklin in 1966 at Roswell Park Comprehensive Cancer Center (formerly known as Roswell Park Memorial Institute), from where it derives its name. [2]
LL-100 panel cell lines cover the full spectrum of human leukemia and lymphoma including T-cell, B-cell and myeloid malignancies. [ 1 ] List of LL-100 cell lines
Lymphoblastoid cell lines established from blood samples of humans who were centenarians (100 years old or older) have significantly higher PARP activity than cell lines from younger (20 to 70 years old) individuals. [37] The Wrn protein is deficient in persons with Werner syndrome, a human premature aging disorder.
Lymphoblastoid cell line, the outcome of lymphocyte infection by Epstein–Barr virus; Light Center Length, the distance between the center of the filament (or arc tube) and a reference plane - usually the bottom of the lamp base