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Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. [2] [9] It is indicated for use in conjunction with castration in the treatment of metastatic castration-resistant prostate cancer (mCRPC), [2] nonmetastatic castration-resistant prostate cancer, [2] and metastatic castration-sensitive prostate ...
Extend health span by reducing the risk of disease at the end of life Be tested for safety and efficacy on hundreds, possibly thousands of people in clinical trials Influence all-cause mortality
[83] [84] [85] This difference in effectiveness in men and women may be related to the fact that NSAAs like flutamide significantly increase androgen levels in men, [35] which counteracts their antiandrogenic potency, [86] but do not increase androgen levels in women. [87]
Apalutamide is a structural analogue of enzalutamide and RD-162. [18] [33] It is a pyridyl variant of RD-162. Enzalutamide and RD-162 were derived from the nonsteroidal androgen RU-59063, which itself was derived from the first-generation NSAA nilutamide and by extension from flutamide. [34]
The researchers say that their early results suggest that this weekly dose of rapamycin could delay ovarian aging by as much as 20%, giving women a potential 5 extra fertile years.
In 2021, the age-adjusted mortality rate for Covid-19 was 131 deaths per 100,000 men compared with 82 deaths per 100,00 women — leading to a 0.33 year difference in life expectancy since 2019 ...
For instance, a 2020 study indicates that the global mean loss of life expectancy (LLE) from air pollution in 2015 was 2.9 years, substantially more than, for example, 0.3 years from all forms of direct violence, albeit a significant fraction of the LLE (a measure similar to years of potential life lost) is considered to be unavoidable.
Nearly one in five new cervical cancers diagnosed from 2009 to 2018 were in women 65 and older, according to a new UC Davis study.But what has experts concerned is that, according to the study ...
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