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Other side effects may include pain or skin changes at the sites of injection, low blood potassium, and allergic reactions. [3] Use during pregnancy is relatively safe for the fetus. [3] NPH insulin is made by mixing regular insulin and protamine in exact proportions with zinc and phenol such that a neutral-pH is maintained and crystals form. [1]
Common side effects include (hypoglycemia, allergic reactions, pain at the injection site, and weight gain. [121] It appears to be safe for use during pregnancy and breastfeeding. [ 122 ] Insulin detemir works by increasing the amount of glucose absorbed by tissues and reducing the amount of glucose produced by the liver.
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Common side effects include nausea, pain at the site of injection, and headache. [2] It may also cause a temporary increase in blood pressure and decrease in heart rate after each dose, and darkening of the gums, face, and breasts. [4] The medication is a peptide and acts by activating the melanocortin receptors. [1] [5]
[23] [24] [25] It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. [ 26 ] [ 27 ] It can be administered by subcutaneous injection or taken orally . [ 14 ] [ 15 ] [ 16 ] [ 28 ] It is sold by Novo Nordisk under the brand names Ozempic [ 14 ] and Rybelsus [ 15 ] for diabetes, and under the brand name ...
The side effect profile in trials of sacubitril/valsartan compared to valsartan alone or enalapril [an angiotensin converting enzyme inhibitor] is very similar, with the incidence of hypotension slightly higher in sacubitril/valsartan, the risk comparable for angioedema, and the chance of hyperkalaemia, renal impairment and cough slightly lower.
Other serious side effects may include medullary thyroid cancer, angioedema, pancreatitis, and kidney injury. [7] Use in pregnancy and breastfeeding is of unclear safety. [ 9 ] Exenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) also known as incretin mimetics . [ 7 ]
Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death.