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Epidemiological (and other observational) studies typically highlight associations between exposures and outcomes, rather than causation. While some consider this a limitation of observational research, epidemiological models of causation (e.g. Bradford Hill criteria) [7] contend that an entire body of evidence is needed before determining if an association is truly causal. [8]
In epidemiology, a clinical case definition, [1] a clinical definition, or simply a case definition [2] lists the clinical criteria by which public health professionals determine whether a person's illness is included as a case in an outbreak investigation—that is, whether a person is considered directly affected by an outbreak.
Conversely, in experimental studies, the epidemiologist is the one in control of all of the factors entering a certain case study. [43] Epidemiological studies are aimed, where possible, at revealing unbiased relationships between exposures such as alcohol or smoking, biological agents , stress , or chemicals to mortality or morbidity .
Case series have a descriptive study design; unlike studies that employ an analytic design (e.g. cohort studies, case-control studies or randomized controlled trials), case series do not, in themselves, involve hypothesis testing to look for evidence of cause and effect (though case-only analyses are sometimes performed in genetic epidemiology ...
The process for selecting and matching cases is identical to a normal case control study. An example of a nested case-control study is Inflammatory markers and the risk of coronary heart disease in men and women, which was a case control analyses extracted from the Framingham Heart Study cohort. [15]
A retrospective cohort study, also called a historic cohort study, is a longitudinal cohort study used in medical and psychological research. A cohort of individuals that share a common exposure factor is compared with another group of equivalent individuals not exposed to that factor, to determine the factor's influence on the incidence of a ...
Porta's Dictionary of Epidemiology defines the case–control study as: "an observational epidemiological study of persons with the disease (or another outcome variable) of interest and a suitable control group of persons without the disease (comparison group, reference group). The potential relationship of a suspected risk factor or an ...
In medicine, a case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient. Case reports may contain a demographic profile of the patient, but usually describe an unusual or novel occurrence. Some case reports also contain a literature review of other reported cases.