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This last requirement makes MS an ill-defined entity, whose borders change every time that a new disease is set apart. Some cases previously considered MS are now considered distinct conditions, like Neuromyelitis optica or antiMOG associated encephalomyelitis. Because of the requirement of distributed lesions, a single lesion (RIS) is not ...
BK-NM-AMT, or βk-NM-αMT, also known as β-keto-N-methyl-αMT or as α,N-dimethyl-β-ketotryptamine, is a serotonin–dopamine releasing agent (SDRA) and putative entactogen of the tryptamine and α-alkyltryptamine families.
Several derivatives of isoDMT have been developed, including the non-hallucinogenic psychoplastogens 5-MeO-isoDMT and AAZ-A-154 (DLX-001; (R)-5-MeO-α-methyl-isoDMT) and the hallucinogen and psychoplastogen 6-MeO-isoDMT.
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
4-HT is a potent agonist of the serotonin 5-HT 2A receptor similarly to psilocin (EC 50 Tooltip half-maximal effective concentration = 38 nM and 21 nM, respectively). [4] It produces serotonergic peripheral effects in animals, [1] [10] shows similar metabolism and metabolic stability to psilocin, [4] and appears to cross the blood–brain barrier and hence is centrally penetrant.
NMT is an alkaloid derived from L-tryptophan that has been found in the bark, shoots and leaves of several plant genera, including Virola, Acacia, Mimosa, and Desmanthus—often together with the related compounds N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). [4]
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N-Ethyltryptamine (NET) is a tryptamine that is structurally related to N-methyltryptamine (NMT) and the psychedelic drugs N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET). [1] It has been found to act as a potent serotonin 5-HT 2A receptor full agonist and serotonin releasing agent. [2]