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The sustained expression of VCAM-1 lasts over 24 hours. Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR [7] and Moesin. [7]
They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs is difficult to assess clinically, but these soluble forms are present in the circulation and may serve as markers for CAMs.
A key generator [1] [2] [3] is a protocol or algorithm that is used in many cryptographic protocols to generate a sequence with many pseudo-random characteristics. This sequence is used as an encryption key at one end of communication, and as a decryption key at the other.
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U.S. farm industry groups want President-elect Donald Trump to spare their sector from his promise of mass deportations, which could upend a food supply chain heavily dependent on immigrants in ...
Jay-Z is accused in a lawsuit of raping a 13-year-old girl with fellow music mogul Sean “Diddy” Combs. The lawsuit was first filed in October but did not list Jay-Z, whose given name is Shawn ...
U.S. President-elect Donald Trump says he wants to make Greenland a part of the United States, renewing an interest first expressed in 2019 when he offered to buy the sprawling Arctic island from ...
VLA-4's primary ligands include VCAM-1 and fibronectin. [4] One activating chemokine is SDF-1 . Following SDF-1 binding, the integrin undergoes a conformational change of the alpha and beta domains that is necessary to confer high binding affinity for the endothelial adhesion molecules.