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There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society , there is no evidence to support wild yam or diosgenin being either safe or effective in humans.
Diosgenin is a chemical precursor for several hormones, starting with the Marker degradation process, which includes synthesis of progesterone. [4] The process was used in the early manufacturing of combined oral contraceptive pills. [5]
Some of the ingredients included in supplements are carcinogenic, including don quai. [1]: 1331 By altering the body's hormonal levels, certain ingredients, including zearalenone, may reduce fertility. [9] One ingredient, kava, may cause liver damage. [2]: 1347 Black cohosh has been shown to have no estrogenic effect in vivo or in vitro.
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May worsen hormone sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids. [17] Insomnia. [17] Goldenseal: orangeroot, yellow puccoon Hydrastis canadensis: Uterotonic [3] Greater celandine: celandine Chelidonium majus: Liver damage [4] Guarana: Paullinia cupana: Agitation and insomnia [3 ...
Bioidentical hormones fit precisely into human hormone receptors while conventional hormones fit "cockeyed"; this mismatch causes serious side effects Synthetic progestins and endogenous progesterone have different binding affinities for different receptors, depending on the model and animal used; these differing pharmacodynamics have not been ...
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