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A drug combination chart designed for harm reduction by TripSit [1] Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals.
A trip sitter—sometimes known as a sober sitter, spotter, or co-pilot—is a term used by recreational or spiritual drug users to describe a person who remains sober to ensure the safety of the drug user while they are under the influence of a drug; they are especially common with first-time experiences or when using psychedelics, dissociatives and deliriants.
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family.
2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.
For example, SNRIs such as venlafaxine are commonly prescribed to treat depression, and the serotonin 5-HT 1A receptor agonist buspirone is prescribed primarily for treatment of anxiety. However, subsequent research contradicted the preceding findings and found that 5-MeO-MiPT did not significantly bind to or inhibit the human monoamine ...
The visible section or "overt" is the syntax that still remains in a sentence word. [15] Within sentence word syntax there are 6 different clause-types: Declarative (making a declaration), exclamative (making an exclamation), vocative (relating to a noun), imperative (a command), locative (relating to a place), and interrogative (asking a ...
If separating words using spaces is also permitted, the total number of known possible meanings rises to 58. [38] Czech has the syllabic consonants [r] and [l], which can stand in for vowels. A well-known example of a sentence that does not contain a vowel is Strč prst skrz krk, meaning "stick your finger through the neck."
As a result, pi–pi and cation–pi interactions are important factors in rational drug design. [24] One example is the FDA-approved acetylcholinesterase (AChE) inhibitor tacrine which is used in the treatment of Alzheimer's disease. Tacrine is proposed to have a pi stacking interaction with the indolic ring of Trp84, and this interaction has ...