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Halicin (SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). [ 1 ] [ 2 ] [ 3 ] Originally, it was researched for the treatment of diabetes , [ 4 ] but development was discontinued for this application due to poor results in testing.
Halocins are bacteriocins produced by halophilic Archaea [1] [2] and a type of archaeocin. [3]Since their discovery in 1982, [4] halocins have been demonstrated to be diverse in a similar ways as the other bacteriocins.
Collins conducted research showing that artificial intelligence (AI) approaches can be used to discover novel antibiotics, such as halicin and abaucin. [1] He serves as the Director of the Antibiotics-AI Project at MIT, which is supported by The Audacious Project , and is a member of the Harvard–MIT Program in Health Sciences and Technology .
The MIT Abdul Latif Jameel Clinic for Machine Learning in Health (commonly, MIT Jameel Clinic; previously, J-Clinic) is a research center at the Massachusetts Institute of Technology (MIT) in the field of artificial intelligence (AI) and health sciences, including disease detection, drug discovery, and the development of medical devices.
[13] [14] In 2020, she was part of the team—with fellow MIT Jameel Clinic faculty lead Professor James J. Collins—that announced the discovery through deep learning of halicin, the first new antibiotic compound for 30 years, which kills over 35 powerful bacteria, including antimicrobial-resistant tuberculosis, the superbug C. difficile, and ...
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