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Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and/or their nuclei. Several key determinants of cell and nuclear size, like ploidy and the regulation of cellular metabolism , are commonly disrupted in tumors . [ 1 ]
Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic. Nuclear atypia can be seen in reactive changes, pre-neoplastic changes and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.
There is marked nuclear pleomorphism, multiple mitoses (one at white arrow) and multinucleated cells (one at black arrow). H&E stain. Date: 2 March 2021, 19:50:22:
Histopathology of glioblastoma, showing high grade astrocytoma features of marked nuclear pleomorphism, multiple mitoses (one at white arrow) and multinucleated cells (one at black arrow), with cells having a patternless arrangement in a pink fibrillary background on H&E stain.
Anaplastic cells display marked pleomorphism (variability). The nuclei are characteristically extremely hyperchromatic (darkly stained) and large. The nuclear-cytoplasmic ratio may approach 1:1 instead of the normal 1:4 or 1:6.
Malignant neoplasm showing marked anaplasia. Note the marked nuclear pleomorphism, bizarre cells and tumor giant cells. Category: Histopathology of giant cell tumors Capillary hemangioma: Micrograph showing capillary hemangioma of skin. Category: Histopathology of capillary hemangioma: Lepromatous leprosy
Pleomorphism may refer to: Pleomorphism (cytology) , variability in the size and shape of cells and/or their nuclei Pleomorphism (microbiology) , the ability of some bacteria to alter their shape or size in response to environmental conditions
[16] [17] It grades breast carcinomas by adding up scores for tubule formation, nuclear pleomorphism, and mitotic count, each of which is given 1 to 3 points. The scores for each of these three criteria are then added together to give an overall final score and corresponding grade.