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C++ based molecule editor and visualizer for in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. Linux, macOS, Unix, Windows: 3-Clause BSD License: Open Chemistry Project: BEDtools "Genome arithmetic"—manipulation of coordinate sets and the extraction of sequences from a BED file. Linux: MIT
DNASTAR Lasergene Molecular Biology Suite Yes Align DNA, RNA, protein, or DNA + protein sequences via a variety of pairwise and multiple sequence alignment algorithms, generate phylogenetic trees to predict evolutionary relationships, explore sequence tracks to view GC content, gap fraction, sequence logos, translation
Genome size ranges (in base pairs) of various life forms. Genome size is the total amount of DNA contained within one copy of a single complete genome.It is typically measured in terms of mass in picograms (trillionths or 10 −12 of a gram, abbreviated pg) or less frequently in daltons, or as the total number of nucleotide base pairs, usually in megabases (millions of base pairs, abbreviated ...
Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic, meaning that one allele of the same gene replaces another allele, or ectopic, meaning that one paralogous DNA sequence converts another.
Indexes the genome with a k-mer lookup table with full sensitivity up to an adjustable number of mismatches. It is best for mapping 15-60 bp sequences to a genome. No No Yes No, multiple processes per search 2003 QPalma Can use quality scores, intron lengths, and computation splice site predictions to perform and performs an unbiased alignment.
Comparing genomes: comparative genomics rely on sequence alignment visualization to compare genomes, identify orthologous and paralogous genes, and study genome evolution across species. [ 9 ] To visualize sequence alignments and their features, researchers often rely on popular bioinformatics software tools such as Clustal Omega , MUSCLE , T ...
The monograph Molecular Evolutionary Genetics Analysis was often used as a textbook for new ways to study molecular evolution. MEGA has been updated and expanded several times and currently all these versions are available from the MEGA website. The latest release, MEGA7, has been optimized for use on 64-bit computing systems. MEGA is in two ...
If the rate of evolution were equal in all sampled lineages (a molecular clock), and if the tree were completely balanced (equal numbers of taxa on both sides of any split, to counter the node density effect), UPGMA should not produce a biased result. These expectations are not met by most datasets, and although UPGMA is somewhat robust to ...