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Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [2] and by the U.S. Food and Drug ...
Here are links to possibly useful sources of information about Phenacetin. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
In the 19th century, it was common for apothecaries to create their own combinations of drugs to combat specific ailments. Some sources credit the Swedish physician Herman Hjorton with creating the product under the name "Hjorton's Powders" in 1903, but it is noted that the main ingredient, phenacetin, had been available since 1887.
phenacetin; There is evidence that a compound of two analgesics with different mechanism of action can have an increased painkilling effect over the sum of the effect of each individual analgesic. [1] Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets.
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic ...
European Union, Canada, Australia Hepatotoxicity [3] Tolrestat (Alredase) 1996 Argentina, Canada, Italy, others Severe hepatotoxicity [3] Triacetyldiphenolisatin: 1971 Australia Hepatotoxicity. [3] Triazolam: 1991 France, Netherlands, Finland, Argentina, UK others Psychiatric adverse drug reactions, amnesia. [3] [66] Triparanol: 1962 France, US
Dr. Harry John Clayton (ca.1887 – 31 October 1928) [1] of Macquarie Street and medical superintendent of the Royal Prince Alfred Hospital, Sydney, took the headache remedy then in general use, composed of phenacetin and caffeine, and by experimenting with the addition of aspirin, arrived at what became the standard formulation known as A.P.C. powder, or in the Royal Prince Alfred Hospital ...
It came in the form of APC (aspirin–phenacetin–caffeine) tablets or powder, containing 42% aspirin and 42% phenacetin plus caffeine. [1] Beckers Ltd - outside view of Bex building. Bex was a product of Beckers Pty Ltd, originally based at Pym Street, Dudley Park, South Australia, [2] but which relocated to Sydney in the 1960s. [3]