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The decay properties of actinium-225 are favorable for usage in targeted alpha therapy (TAT); clinical trials have demonstrated the applicability of radiopharmaceuticals containing 225 Ac to treat various types of cancer. However, the scarcity of this isotope resulting from its necessary synthesis in cyclotrons limits its potential applications.
Some α emitting isotopes such as 225 Ac and 213 Bi are only available in limited quantities from 229 Th decay, although cyclotron production is feasible. [9] [10] [11] Among alpha-emitting radiometals according to availability, chelation chemistry, and half-life, 212 Pb is also a promising candidate for targeted alpha-therapy.
A set of radioimmunotherapy drugs that rely upon an alpha-emitting isotope (e.g., bismuth-213 or, preferably, actinium-225), rather than a beta emitter, as the killing source of radiation is being developed. Several phase II clinical trials for the treatment of acute myeloid leukemia have been carried out using alpha-emitting RITs. [10] [11]
The experience was harrowing at times, like when she underwent grueling rounds of chemotherapy, (“My first round felt like a giant root canal,” she recalls.“My jaw hurt so bad like someone ...
Clinical trials of α-emitters are underway due to their higher potency and ability to induce double-strand DNA breaks. There are multiple Actinium-225 based PSMA studies that will be launched in 2024. If these prove successful, there is potential for further studies and clinical trials to be done using α-emitters. [39]
(Reuters) -A Washington jury on Tuesday ordered Bayer to pay $100 million to four people who say they were sickened by toxic chemicals known as PCBs at a Seattle-area school, but found the company ...
In clinical trials, the non-opioid medication received high patient satisfaction ratings, with 83% reporting "good" to "excellent" pain relief in real-world applications, Cheng noted.
228 Ac and 225 Ac are extremely rare, so almost all natural actinium is 227 Ac. The most stable isotopes are 227 Ac with a half-life of 21.772 years, 225 Ac with a half-life of 10.0 days, and 226 Ac with a half-life of 29.37 hours. All other isotopes have half-lives under 10 hours, and most under a minute.