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NCCN Guidelines Version 2.2025. - Chronic Myeloid Leukemia.
Chronic myeloid leukemia (CML) accounts for 15% of adult leukemias. The median age of disease onset is 67 years; however, CML occurs in all age groups (SEER statistics). In 2023, an estimated 8,930 people will be diagnosed with CML in the United States, and 1,310 people will die of the disease. 1
The full NCCN Guidelines for CML (available at NCCN.org) discuss the clinical management of CML in all 3 phases (chronic, accelerated, or blast phase). Evaluation for diseases other than CML as outlined in the NCCN Guidelines for MPN is recommended for all patients with BCR-ABL1 –negative MPN.
CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase in developed countries. Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase-CML.
These updated guidelines on chronic myeloid leukaemia provide updated treatment recommendations including the monitoring and management of side effects, as well as a new treatment algorithm for chronic phase chronic myeloid leukaemia patients.
These NCCN Guidelines for Patients are based on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Chronic Myeloid Leukemia, Version 1.2025 – August 8, 2024. View the NCCN Guidelines for Patients free online.
The incidence of chronic myeloid leukaemia (CML) ranges between 10 and 15 cases/10 6 /year without any major geographic or ethnic differences [1]. The median age at diagnosis ranges between 60 and 65 years in Europe, but is considerably lower in countries with a younger population. The prevalence of CML is steadily rising due to the substantial ...
Tyrosine kinase inhibitor therapy is a highly effective first-line treatment option for all patients with newly diagnosed chronic phase CML. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with chronic phase CML.
Specialty care for complications of chronic TKI therapy is required for optimal management. CML is no longer a disease that is fatal in a few years. Rather, it has evolved into a chronic...
Treatment options for people with chronic myeloid leukemia (CML) depend on the phase of their disease (chronic, accelerated, or blast phase), their age and overall health, other prognostic factors, and the availability of a stem cell donor with a matching tissue type (for a possible stem cell transplant).