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Chemotherapy can boost tumor immunity in two main ways: (a) by killing cancer cells through immunogenic cell death, and (b) by affecting both cancerous and normal cells in the tumor environment. Despite this, many chemotherapy treatments can also suppress the immune system by causing lymphopenia or impairing lymphocyte function.
For example, assuming a 99% kill per cycle of chemotherapy, a tumor of 10 11 cells would be reduced to less than one cell with six treatment cycles: 10 11 * 0.01 6 < 1. [3] However, the tumor can also re-grow during the intervals between treatments, limiting the net reduction of each fractional kill. [4]
Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA ...
Chemotherapy kills cancer cells which can help prevent the disease returning. There are many types of chemotherapy drugs and patients can take the treatment as tablets at home, with regular check ...
GTFC is designed to specifically target cancer cells with genetic mutations, he said, so that more chemo gets into the tumor. "While only 5% to 7% of conventional chemotherapy administered through ...
Cyclophosphamide (CP), also known as cytophosphane among other names, [3] is a medication used as chemotherapy and to suppress the immune system. [4] As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. [4]
Chemotherapy will be the standard treatment for many of those patients. Chemotherapy drugs work by killing cancer cells. While often effective, they can also come with major side effects because ...
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combination chemotherapy. The majority of drugs used in cancer chemotherapy are cytostatic, many via ...
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