Search results
Results from the WOW.Com Content Network
Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. [2] Neutrophils are the immune system's first line of defense against infection and have conventionally been thought to kill invading pathogens through two strategies: engulfment of microbes and secretion ...
Macrophages and neutrophils, in particular, play a central role in the inflammatory process by releasing proteins and small-molecule inflammatory mediators that control infection but can damage host tissue. In general, phagocytes aim to destroy pathogens by engulfing them and subjecting them to a battery of toxic chemicals inside a ...
The engulfing of a pathogen by a phagocyte. In a multicellular organism's immune system, phagocytosis is a major mechanism used to remove pathogens and cell debris. The ingested material is then digested in the phagosome. Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytized.
It is thought that the bactericidal properties of HClO are enough to kill bacteria phagocytosed by the neutrophil, but this may instead be a step necessary for the activation of proteases. [35] Though neutrophils can kill many microbes, the interaction of neutrophils with microbes and molecules produced by microbes often alters neutrophil turnover.
Neutrophils contain neutrophil extracellular traps (NETs), composed of granule and nuclear constituents, which play a role in breaking up and killing bacteria that has invaded the immune system. NETs, composed of activated neutrophils, are fragile structures consisting of smooth stretches and globular domains, as shown via high-resolution ...
Phagolysosome resolution is the final stage in the phagocytic process, involving the breakdown of engulfed material and the recycling of phagolysosomal components. Most studies do not image the process of phagocytosis to completion, instead using lysosome fusion or acidification of the phagolysosome lumen as endpoints.
The most common bacteria and viruses on your phone are fecal bacteria like E. coli or Salmonella, as well as viruses like norovirus, the flu, and rhinovirus (the common cold), says Saggar.
An example of neutrophil swarming behavior by neutrophil extracellular traps. The neutrophil (green) surround branches of the Aspergillus Fumigatus (light blue) in infected lung tissue in a swarming manner and transport the branches to the neutrophil aggregates on the left. The dark blue color indicates lung tissue and the red color indicates DNA.