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Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers. The editor-in-chief is Atta-ur-Rahman, FRS (Kings College University of Cambridge Cambridge, UK). The journal covers developments in medicinal chemistry and rational drug design and publishes original research reports and review papers. [2]
The journal covers developments in "medicinal chemistry and rational drug design for the discovery of anti-cancer agents" and publishes original research reports and review papers. [1] It is related to the journal Current Medicinal Chemistry and was established in 2001 as Current Medicinal Chemistry – Anti-Cancer Agents. [2]
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use.
However, now, after two decades of combinatorial chemistry, it has been pointed out that despite the increased efficiency in chemical synthesis, no increase in lead or drug candidates has been reached. [57] This has led to analysis of chemical characteristics of combinatorial chemistry products, compared to existing drugs or natural products.
Current Topics in Medicinal Chemistry is a biweekly peer-reviewed medical journal published by Bentham Science Publishers. It includes review articles on all aspects of medicinal chemistry, including drug design. The current editor-in-chief is Jia Zhou (University of Texas, Medical Branch).
Molecular medicine is a broad field, where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. [1]
An unusual component of the artemisinin molecules is an endoperoxide 1,2,4-trioxane ring. This is the main antimalarial centre of the molecule. [23] Modifications at carbon 10 (C10) position give rise to a variety of derivatives which are more powerful than the original compound. [24]
[3] [20] [21] [22] Siderophores are then recognized by cell specific receptors on the outer membrane of the cell. [ 2 ] [ 3 ] [ 23 ] In fungi and other eukaryotes, the Fe-siderophore complex may be extracellularly reduced to Fe 2+ , while in many cases the whole Fe-siderophore complex is actively transported across the cell membrane.