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Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). Subcategories ...
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Hepatotoxicity. [14] Ketorolac: 1993 France, Germany, others Hemorrhage, Kidney Failure. [3] L-tryptophan: 1989 Germany, UK Eosinophilic myalgia syndrome. [3] Still sold in the US Levamisole (Ergamisol) 1999 US Still used as veterinary drug and as a human antihelminthic in many markets; listed on the WHO List of Essential Medicines.
Myelosupression, embryo-fetal toxicity, hepatotoxicity (rare) [19] Trabectedin: IV Alkylates DNA. Advanced liposarcoma and leimyosarcoma Bone marrow suppression, rhabdomyolysis, embryo-fetal toxicity, capillary leak syndrome, hepatotoxicity [20] 1.10 Platinum compounds: Carboplatin: IV: Reacts with DNA, inducing apoptosis, non-cell cycle specific.
This includes mostly drug-induced hepatotoxicity, (DILI) which may generate many different patterns over liver disease, including . cholestasis; necrosis; acute hepatitis and chronic hepatitis of different forms,
People with cirrhosis or liver damage are often advised to avoid drugs that could further harm the liver. [120] These include several drugs such as anti-depressants, certain antibiotics, and NSAIDs (like ibuprofen). [120] These agents are hepatotoxic as they are metabolized by the liver. If a medication that harms the liver is still recommended ...
A drug nomogram developed in 1975, called the Rumack–Matthew nomogram, estimates the risk of toxicity based on the serum concentration of paracetamol at a given number of hours after ingestion. [10] To determine the risk of potential hepatotoxicity, the paracetamol level is traced along the nomogram.