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Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
The effects of psychedelics on neuroplasticity appear to be dependent on serotonin 5-HT 2A receptor activation, as they are abolished in 5-HT 2A receptor knockout mice. [7] Non-hallucinogenic serotonin 5-HT 2A receptor agonists, like tabernanthalog and lisuride , have also been found to increase neuroplasticity, and to a magnitude comparable to ...
Unlike traditional antidepressants that target the neurotransmitters serotonin and/or norepinephrine, ketamine targets glutamate — the most abundant chemical messenger in the brain, Feifel said.
Effects of mixing ketamine with other drugs Ketamine can be concerning if it’s mixed with other drugs, Alan says. “When ketamine is mixed with things like alcohol and opioids, it can make the ...
A 2000 landmark study showcased the drug's antidepressant and anti-suicidal effects, and more recent studies have supported ketamine's high rate of success in treating persistent depression.
The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.
Last fall, the FDA put out a warning on some types of ketamine, saying the drug is not approved for any psychiatric disorder and warned about taking it at home, which can be even more risky ...