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Bromocriptine, originally marketed as Parlodel and subsequently under many brand names, [1] is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.
Type 2 diabetes is the most common type of diabetes. Treatments include agents that (1) increase the amount of insulin secreted by the pancreas, (2) increase the sensitivity of target organs to insulin, (3) decrease the rate at which glucose is absorbed from the gastrointestinal tract, and (4) increase the loss of glucose through urination.
Prolactin inhibitors are mainly used to treat hyperprolactinemia (high prolactin levels). [1] Agonists of the dopamine D 2 receptor such as bromocriptine and cabergoline are able to strongly suppress pituitary prolactin secretion and thereby decrease circulating prolactin levels, and so are most commonly used as prolactin inhibitors. [1]
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Dopamine receptors have five subtypes, D 1 through D 5, the subtypes can be divided into two subclasses due to their mechanism of action on adenylate cyclase enzyme, D 1-like receptors (D 1 and D 5) and D 2-like receptors (D 2, D 3 and D 4). D 1-like receptors are primarily coupled to Gα s/olf proteins and activates adenylate cyclase which ...
If spiperone was added as soon as 1 min after I, the antagonist was unable to block the complete expression of the I inhibition. Evidently, I is a functionally irreversible dopamine agonist for at least the 4 h of these studies." source: European Journal of Pharmacology 1984, 99(1), p.85 Nagelfar 19:03, 20 October 2008 (UTC)
A drug is considered highly soluble when the highest dose strength is soluble in 250 ml or less of aqueous media over the pH range of 1 to 6.8. The volume estimate of 250 ml is derived from typical bioequivalence study protocols that prescribe administration of a drug product to fasting human volunteers with a glass of water.
50–250 mg 1×/2–4 weeks Testosterone undecanoate: Aveed, Nebido: Oil solution: 750–1,000 mg 1×/10–14 weeks Testosterone buciclate a – Aqueous suspension: 600–1,000 mg 1×/12–20 weeks Implant: Testosterone: Testopel: Pellet: 150–1,200 mg/3–6 months Notes: Men produce about 3 to 11 mg of testosterone per day (mean 7 mg/day in ...