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  2. Ampicillin - Wikipedia

    en.wikipedia.org/wiki/Ampicillin

    Pregnancy increases the clearance of ampicillin by up to 50%, and a higher dose is thus needed to reach therapeutic levels. [25] [27] Ampicillin crosses the placenta and remains in the amniotic fluid at 50–100% of the concentration in maternal plasma; this can lead to high concentrations of ampicillin in the newborn. [27]

  3. Cmax (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Cmax_(pharmacology)

    C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.

  4. Ampicillin/sulbactam - Wikipedia

    en.wikipedia.org/wiki/Ampicillin/sulbactam

    However, when ampicillin is given in combination with sulbactam, regrowth of bacteria has been seen when sulbactam levels fall below certain concentrations. As with many other antibiotics, under-dosing of ampicillin/sulbactam may lead to resistance. [14] Ampicillin/sulbactam has poor absorption when given orally. [13]

  5. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.

  6. Bioavailability - Wikipedia

    en.wikipedia.org/wiki/Bioavailability

    Where AUC refers to the concentration of the drug in the blood over time t = 0 to t = ∞, C max refers to the maximum concentration of the drug in the blood. When T max is given, it refers to the time it takes for a drug to reach C max.

  7. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...

  8. Boomers are sad they may never be grandparents as fewer ... - AOL

    www.aol.com/finance/boomers-sad-may-never...

    The birth rate in America has long been on a decline, with the fertility rate reaching historic lows in 2023. More women between ages 25 to 44 aren’t having children, for a number of reasons.

  9. Loading dose - Wikipedia

    en.wikipedia.org/wiki/Loading_dose

    That immediately gets the drug's concentration in the body up to the therapeutically-useful level. First day: 1000 mg; the body clears 100 mg, leaving 900 mg. On the second day, the patient takes 100 mg, bringing the level back to 1000 mg; the body clears 100 mg overnight, still leaving 900 mg, and so forth.