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  2. Glucokinase - Wikipedia

    en.wikipedia.org/wiki/Glucokinase

    Glucose-sensitive neurons of the hypothalamus. In response to rising or falling levels of glucose, cells in the hypothalamus polarize or depolarize. Among the neuroendocrine reactions of the central nervous system to hypoglycemia is activation of the adrenergic responses of the autonomic nervous system. Glucokinase likely serves as a glucose ...

  3. Insulin tolerance test - Wikipedia

    en.wikipedia.org/wiki/Insulin_tolerance_test

    An insulin tolerance test (ITT) is a medical diagnostic procedure during which insulin is injected into a patient's vein, after which blood glucose is measured at regular intervals. This procedure is performed to assess pituitary function, adrenal function, insulin sensitivity , [ 1 ] [ 2 ] and sometimes for other purposes.

  4. Homeostatic model assessment - Wikipedia

    en.wikipedia.org/wiki/Homeostatic_model_assessment

    IR is insulin resistance and %β is the β-cell function (more precisely, an index for glucose tolerance, i.e. a measure for the ability to counteract the glucose load). Insulin is given in μU/mL. [7] Glucose and insulin are both during fasting. [2] This model correlated well with estimates using the euglycemic clamp method (r = 0.88). [2]

  5. Hypothalamus - Wikipedia

    en.wikipedia.org/wiki/Hypothalamus

    The hypothalamus contains neurons that react strongly to steroids and glucocorticoids (the steroid hormones of the adrenal gland, released in response to ACTH). It also contains specialized glucose-sensitive neurons (in the arcuate nucleus and ventromedial hypothalamus), which are important for appetite.

  6. 12 reasons you aren't losing weight even though you're eating ...

    www.aol.com/lifestyle/12-reasons-arent-losing...

    She adds that inflammation and oxidative stress interfere with your hypothalamus, the brain's control center ... "Menopausal changes can affect insulin sensitivity, causing shifts in ghrelin (the ...

  7. Hypopituitarism - Wikipedia

    en.wikipedia.org/wiki/Hypopituitarism

    A similar stimulation test using corticotropin-releasing hormone (CRH) is not sensitive enough for the purposes of the investigation. If the insulin tolerance test yields an abnormal result, a further test measuring the response of the adrenal glands to synthetic ACTH (the ACTH stimulation test) can be performed to confirm the diagnosis. [21]

  8. Glucose clamp technique - Wikipedia

    en.wikipedia.org/wiki/Glucose_clamp_technique

    The hyperglycemic clamp, which requires maintaining a high blood sugar level by perfusion or infusion with glucose, is a way to quantify how fast beta-cells respond to glucose. The hyperinsulinemic clamp, which requires maintaining a high insulin level by perfusion or infusion with insulin, is a way to quantify how sensitive the tissue is to ...

  9. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    The glucose diffuses in the beta-cell facilitated by a GLUT-2 vesicle. Inside the beta cell, the following process occurs: Glucose gets converted to glucose-6-phosphate (G6P) through glucokinase, and G6P is subsequently oxidized to form ATP. This process inhibits the ATP-sensitive potassium ion channels of the cell causing the potassium ion ...

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