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Neurotrophic factors also promote the initial growth and development of neurons in the central nervous system and peripheral nervous system, and they are capable of regrowing damaged neurons in test tubes and animal models. [1] [4] Some neurotrophic factors are also released by the target tissue in order to guide the growth of developing axons.
According to the United States National Library of Medicine's medical subject headings, the term neurotrophin may be used as a synonym for neurotrophic factor, [5] but the term neurotrophin is more generally reserved for four structurally related factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). [6]
LIFRβ acts as a docking site for the STAT transcription factors. JAK kinase phosphorylates STAT proteins, which dissociate from the receptor and translocate to the nucleus to regulate gene expression. GDNF: Glial derived neurotrophic factor is a member of the TGFb family of proteins, and is a potent trophic factor for striatal neurons. The ...
Neurturin is an example of a trophic factor that is difficult to utilize clinically because of its inability to cross the blood-brain barrier of the CNS (central nervous system). Ceregene sponsored a double-blind phase II clinical trial of CERE-120, a viral vector mediated gene transfer drug that allows for the continuous delivery of neurturin ...
Neurotrophic factors are biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons. [2] [3] [4] Examples of notable neurotrophic factors include: Insulin-like growth factor-1 (IGF-1) Glial cell line-derived neurotrophic factor (GDNF)
4803 18049 Ensembl ENSG00000134259 ENSMUSG00000027859 UniProt P01138 P01139 RefSeq (mRNA) NM_002506 NM_001112698 NM_013609 RefSeq (protein) NP_002497 NP_001106168 NP_038637 Location (UCSC) Chr 1: 115.29 – 115.34 Mb Chr 3: 102.38 – 102.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the ...
[15] [16] Other evidence suggests that gene-therapy induced expression of neurotrophic factors within the target muscle itself can also help enhance axon regeneration. [ 17 ] [ 18 ] Accelerating neuroregeneration and the reinnervation of a denervated target is critically important in order to reduce the possibility of permanent paralysis due to ...
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3).