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Although propofol is widely used in the adult ICU setting, the side effects associated with medication seem to be more concerning in children. In the 1990s, multiple reported deaths of children in ICUs associated with propofol sedation prompted the FDA to issue a warning. [61] As a respiratory depressant, propofol frequently produces apnea.
Procedural sedation and analgesia (PSA) is a technique in which a sedating/dissociative medication is given, usually along with an analgesic medication, in order to perform non-surgical procedures on a patient. The overall goal is to induce a decreased level of consciousness while maintaining the patient's ability to breathe on their own.
This level, called moderate sedation/analgesia or conscious sedation, causes a drug induced depression of consciousness during which the patient responds purposefully to verbal commands, either alone or accompanied with light physical stimulation. Breathing tubes are not required for this type of anesthesia. This is twilight anesthesia. [2]
Sedation is typically used in minor surgical procedures such as endoscopy, vasectomy, or dentistry and for reconstructive surgery, some cosmetic surgeries, removal of wisdom teeth, or for high-anxiety patients. [2] Sedation methods in dentistry include inhalation sedation (using nitrous oxide), oral sedation, and intravenous (IV) sedation ...
Fospropofol is a prodrug of propofol; as an organophosphate it is metabolized by alkaline phosphatases to phosphate and formaldehyde and the active metabolite, propofol. Pharmacodynamics [ edit ]
Propofol for sedation for intubation; Switching from oxygen to a mixture of oxygen and inhalational anesthetic once intubation is complete; Laryngoscopy and intubation are both very stimulating. The process of induction blunts the response to these manoeuvres while simultaneously inducing a near-coma state to prevent awareness.
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General anesthetics that agonize them are typically used to induce a state of sedation and/or unconsciousness. Such drugs include propofol, etomidate, isoflurane, benzodiazepines (midazolam, lorazepam, diazepam), and barbiturates (sodium thiopental, methohexital). [2] [3] [4]