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The test was first introduced in 1956, using iodine-131 diodrast. [25] [26] Later developments included iodine-131, and then iodine-123, labelled ortho-Iodohippuric acid (OIH, marketed as Hippuran). [27] [28] 99m Tc-MAG3 has replaced 131 I-OIH because of better quality imaging regardless of the level of kidney function, [29] and lower radiation ...
Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment. One side effect of treatment is an initial period of a few days of increased hyperthyroid symptoms. This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood stream.
Iodine-129 (129 I) is a long-lived radioisotope of iodine that occurs naturally but is also of special interest in the monitoring and effects of man-made nuclear fission products, where it serves as both a tracer and a potential radiological contaminant.
Often called the father of nuclear medicine, Lawrence treated a leukemia patient with radiophosphorus, which was the first time a radioactive isotope has been used to treat human patients. [4] Another pioneer in the field, Sam Seidlin, in partnership with Saul Hertz, treated a case of thyroid cancer with radioactive iodine (I-131) 1946. [5]
Iodine-123 (123 I) is a radioactive isotope of iodine used in nuclear medicine imaging, including single-photon emission computed tomography (SPECT) or SPECT/CT exams. The isotope's half-life is 13.2232 hours; [1] the decay by electron capture to tellurium-123 emits gamma radiation with a predominant energy of 159 keV (this is the gamma primarily used for imaging).
Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Iodine-125 is a radioactive isotope of iodine that decays by electron capture with a physical half-life of 60.14 days. The biological half-life in normal individuals for iodine (125 I) human albumin has been reported to be approximately 14 days. Its radioactivity is excreted almost exclusively via the kidneys.
Iodine-131 comprises about 2% of radioactive materials in a cloud of dust stemming from a nuclear test, and causes thyroid problems if ingested. [7] The "John" shot of Plumbbob, on July 19, 1957, was the first test firing of the nuclear-tipped AIR-2 Genie air-to-air rocket designed to destroy incoming enemy bombers with a nuclear explosion.