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Zinc L-carnosine (beta-alanyl-L-histidinato zinc [1]) (N-(3-aminopropionyl)-L-histidinato zinc [2]), often simply called zinc carnosine, and also known as polaprezinc, [3] is a mucosal protective [4] [5] chelate compound of zinc and L-carnosine invented by Hamari Chemicals, Ltd. [6] [7] It is a quadridentate 1:1 complex of a polymeric nature. [6]
Carnosine (beta-alanyl-L-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. [citation needed] Carnosine was discovered by Russian chemist Vladimir Gulevich. [1] Carnosine is naturally produced by the body in the liver [2] from beta-alanine and histidine.
β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine, not histidine. [6] Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes, and increase total muscular work done.
The Best L-Glutamine Supplements, According to Registered Dietitians. Kelsey Kunik, RDN. April 29, 2024 at 12:41 PM. Experts Recommend This L-Glutamine Supplement
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Anserine is a derivative of carnosine, which has been methylated. [2] Both anserine and carnosine chelate copper. [3] Due to its methylation, anserine is more stable in serum and resistant to degradation than carnosine. [4] Anserine can be found in the skeletal muscle and brain of mammals and birds. [2]
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