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IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids , which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of ...
ERT has also been used to treat patients with severe combined immunodeficiency (SCID) resulting from an adenosine deaminase deficiency . [2] Other treatment options for patients with enzyme or protein deficiencies include substrate reduction therapy, gene therapy, and bone-marrow derived stem cell transplantation. [1] [3] [4]
Bcl2 and Bcl-w [7] were the first two discovered, then in 2016, the IRF4 (interferon regulatory factor 4) gene was announced after a study of 6,000 people living in five Latin American countries. However, it found that environmental factors controlled about 70% of cases of hair greying.
Poor diet in early childhood affects the number of neurons in parts of the brain. [1]Nutritional neuroscience is the scientific discipline that studies the effects various components of the diet such as minerals, vitamins, protein, carbohydrates, fats, dietary supplements, synthetic hormones, and food additives have on neurochemistry, neurobiology, behavior, and cognition.
There's compelling research behind the F-factor diet. Zuckerbrot cites one 2009 study , published in the journal Nutritional Review, that found high-fiber, low-fat diets may be more effective for ...
[3] [4] [5] CD49b belongs to the integrin family and is a receptor for many (extracellular) matrix and non-matrix molecules. CD49b provides only little contribution to the differentiation and function of Tr1 cells. [3] They characteristically produce high levels of IL-10, IFN-γ, IL-5 and also TGF- β but neither IL-4 nor IL-2. [6]
Cori Disease, Debrancher Deficiency, Forbes Disease [1] Micrograph of glycogen storage disease with histologic features consistent with Cori disease. Liver biopsy. H&E stain. Specialty: Endocrinology Symptoms: Hypotonia [2] Causes: AGL gene mutation [3] Diagnostic method: Biopsy, Elevated transaminases [4] Treatment: Currently no cure, Diet ...