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Modafinil is also approved for stimulating wakefulness in people with sleep apnea and shift work sleep disorder. [3] It is taken by mouth. [3] [8] Modafinil is not approved by the US Food and Drug Administration (FDA) for use in people under 17 years old. [8] Common side effects of Modafinil include anxiety, insomnia, dizziness, and headache.
Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders , including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
Flmodafinil (developmental code names CRL-40,940, NLS-4, JBG01-41), also known as bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical conditions.
A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.
Chemical structure of modafinil. This page lists chemical compounds similar to modafinil, known as modafinil analogues and derivatives. These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way (atypical dopamine reuptake inhibitor or DRI).
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Treatment of excessive daytime sleepiness (EDS) relies on identifying and treating the underlying disorder which may cure the person from the EDS. Drugs like modafinil, [22] armodafinil, [23] pitolisant [24] (Wakix), sodium oxybate (Xyrem) oral solution, have been
Long-term use may increase the risk of both cognitive and physical decline. [14] [15] It is unclear whether they affect the risk of death generally. [14] However, in older adults they do appear to increase the risk of death. [16] Possible effects of anticholinergics include: