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Doxycycline, doxycycline monohydrate and doxycycline hyclate are yellow, crystalline powders with a bitter taste. The latter smells faintly of ethanol , a 1% aqueous solution has a pH of 2–3, and the specific rotation is [ α ] D 25 {\displaystyle [\alpha ]_{D}^{25}} −110° cm 3 /dm·g in 0.01 N methanolic hydrochloric acid .
It is used as a precursor in the industrial synthesis of doxycycline hyclate. [citation needed] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. [1]
Here are links to possibly useful sources of information about Doxycycline. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements). Minocycline can be taken with dairy products because it does not chelate calcium as readily, although dairy products do decrease absorption of minocycline slightly.
Macrolides are not to be used on nonruminant herbivores, such as horses and rabbits. They rapidly produce a reaction causing fatal digestive disturbance. [5] It can be used in horses less than one year old, but care must be taken that other horses (such as a foal's mare) do not come in contact with the macrolide treatment.
The horse may or may not be pyrexic (fevered). The limb may occasionally ooze serum. The limb may occasionally ooze serum. In ulcerative lumphangitis, "cording" of the lymphatics and the formation of hard nodules and abscesses may also occur; occasionally, a greenish, malodorous discharge is present.
Benadryl, the brand name of the generic antihistamine diphenhydramine, is not labeled for use in dogs but has remained a popular choice among veterinarians, dog groomers, and dog-owning families ...
Equine drug testing is a form of drug testing applied to performance horses in regulated competition. Most common in racehorses, drug tests are also performed on horses in endurance riding and in international competition such as the Olympics and FEI-sanctioned competition.