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A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [12] which are the sources of its stimulant and thermogenic effects. [3]
The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. . However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain phenylephrine HCl 10 mg as the nasal ...
The elimination half-life of pseudoephedrine on average is 5.4 hours [2] and ranges from 3 to 16 hours depending on urinary pH. [1] [11] At a pH of 5.6 to 6.0, the elimination half-life of pseudoephedrine was 5.2 to 8.0 hours. [11]
Reported by the joint conference committee on December 8, 2005; agreed to by the House on December 14, 2005 (251-174, Roll call vote 627, via Clerk.House.gov, in lieu of H.R. 3199) and by the Senate on March 2, 2006 (89-10, Roll call vote 29, via Senate.gov, in lieu of H.R. 3199) Signed into law by President George W. Bush on March 9, 2006
The National Precursor Log Exchange (NPLEx) is a real-time electronic logging system which tracks sales of the methamphetamine precursors ephedrine and pseudoephedrine in the United States. The program is operated by the National Association of Drug Diversion Investigators (NADDI), funded by manufacturers of pseudoephedrine medicine, and ...
Because it contains pseudoephedrine, its purchase in the United States was severely restricted by the Combat Methamphetamine Epidemic Act of 2005 over fears that any product containing pseudoephedrine can be used to make methamphetamine. [1]
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