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The species most readily grows at low pH levels (below 5.0), and has an optimum growth temperature of 37 °C. ... and vaginal cavities of mammals. [9]
To control bacterial growth, the vagina is normally slightly acidic with a pH of 3.8–4.2. A swab of the discharge is put onto litmus paper to check its acidity. A pH greater than 4.5 is considered alkaline and is suggestive of bacterial vaginosis.
The number of progesterone receptors was increased in the vaginal stroma and epithelium, which indicates that ospemifene has "estrogenic activity." [10] Two 12-week phase 3 clinical trials were performed for ospemifene. [14] One evaluated the effects of Ospemifene on vaginal tissue thickness, composition and vaginal pH.
The vaginal microbiota of adolescent girls aged 13 to 18 years is similar to women of reproductive age, [146] who have an average vaginal pH of 3.8–4.5, [94] but research is not as clear on whether this is the same for premenarcheal or perimenarcheal girls. [146]
The discharge is irritating to the vagina and the surrounding skin. low (4.0–4.5) Atrophic vaginitis [24] [25] Usually causes scant vaginal discharge with no odor, dry vagina and painful intercourse. These symptoms are usually due to decreased hormones usually occurring during and after menopause. Current term is Genitourinary syndrome of ...
Studies of proteins adapted to low pH have revealed a few general mechanisms by which proteins can achieve acid stability. In most acid stable proteins (such as pepsin and the soxF protein from Sulfolobus acidocaldarius ), there is an overabundance of acidic residues which minimizes low pH destabilization induced by a buildup of positive charge.
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