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  2. Progesterone receptor - Wikipedia

    en.wikipedia.org/wiki/Progesterone_receptor

    The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone . In humans, PR is encoded by a single PGR gene residing on chromosome 11q 22, [ 5 ] [ 6 ] [ 7 ] it has two isoforms, PR-A and PR-B , that differ in their ...

  3. Selective progesterone receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_progesterone...

    A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone.A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some ...

  4. Progestogen (medication) - Wikipedia

    en.wikipedia.org/wiki/Progestogen_(medication)

    Progesterone interacts with membrane progesterone receptors, but interaction of progestins with these receptors is less clear. [165] [166] In addition to their progestogenic activity, many progestogens have off-target activities such as androgenic, antiandrogenic, estrogenic, glucocorticoid, and antimineralocorticoid activity. [1] [2] [47]

  5. Pharmacodynamics of progesterone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...

  6. Pregnancy hormones - Wikipedia

    en.wikipedia.org/wiki/Pregnancy_hormones

    Progesterone is an endogenous steroid hormone synthesized by the placenta during pregnancy. Progesterone production is regulated by the hypothalamic-pituitary-gonadal axis . The HPG axis regulates the release of both central and peripherally generated ovarian hormones.

  7. Progestogen-only pill - Wikipedia

    en.wikipedia.org/wiki/Progestogen-only_pill

    Progestogens share the common feature of being able to bind to the body's progesterone receptors and enact a physiological effect similar to naturally occurring progesterone. [11] Still, there are differences between progestogens, and various organizational systems exist to categorize the progestogen hormones used in oral contraception medications.

  8. Medroxyprogesterone acetate - Wikipedia

    en.wikipedia.org/wiki/Medroxyprogesterone_acetate

    Progesterone, via transformation into neurosteroids such as 5α-dihydroprogesterone, 5β-dihydroprogesterone, allopregnanolone, and pregnanolone (catalyzed by the enzymes 5α-and 5β-reductase and 3α- and 3β-HSD), is a positive allosteric modulator of the GABA A receptor, and is associated with a variety of effects mediated by this property ...

  9. Progesterone (medication) - Wikipedia

    en.wikipedia.org/wiki/Progesterone_(medication)

    Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.