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  2. Progesterone receptor - Wikipedia

    en.wikipedia.org/wiki/Progesterone_receptor

    The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone . In humans, PR is encoded by a single PGR gene residing on chromosome 11q 22, [ 5 ] [ 6 ] [ 7 ] it has two isoforms, PR-A and PR-B , that differ in their ...

  3. Progestogen (medication) - Wikipedia

    en.wikipedia.org/wiki/Progestogen_(medication)

    Progesterone interacts with membrane progesterone receptors, but interaction of progestins with these receptors is less clear. [165] [166] In addition to their progestogenic activity, many progestogens have off-target activities such as androgenic, antiandrogenic, estrogenic, glucocorticoid, and antimineralocorticoid activity. [1] [2] [47]

  4. Vilaprisan - Wikipedia

    en.wikipedia.org/wiki/Vilaprisan

    Vilaprisan (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name) (developmental code name BAY-1002670) is a synthetic and steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis and uterine fibroids.

  5. Pharmacodynamics of progesterone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...

  6. Etonogestrel - Wikipedia

    en.wikipedia.org/wiki/Etonogestrel

    Etonogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [16] It works by stopping ovulation , thickening the mucus around the opening of the cervix , and altering the lining of the uterus . [ 17 ]

  7. Progesterone (medication) - Wikipedia

    en.wikipedia.org/wiki/Progesterone_(medication)

    Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.

  8. Segesterone acetate - Wikipedia

    en.wikipedia.org/wiki/Segesterone_acetate

    SGA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1] [3] [9] [10] It has some affinity for the glucocorticoid receptor and has no other important hormonal activity. [1] [3] [9] [10]

  9. Selective progesterone receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_progesterone...

    A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone.A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some ...