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  2. 6-Pyruvoyltetrahydropterin synthase deficiency - Wikipedia

    en.wikipedia.org/wiki/6-Pyruvoyltetrahydropterin...

    It is a recessive disorder that is accompanied by hyperphenylalaninemia. Commonly reported symptoms are initial truncal hypotonia, subsequent appendicular hypertonia, bradykinesia, cogwheel rigidity, generalized dystonia, and marked diurnal fluctuation.

  3. Tetrahydrobiopterin deficiency - Wikipedia

    en.wikipedia.org/wiki/Tetrahydrobiopterin_deficiency

    Tetrahydrobiopterin deficiency (THBD, BH 4 D) is a rare metabolic disorder that increases the blood levels of phenylalanine.Phenylalanine is an amino acid obtained normally through the diet, but can be harmful if excess levels build up, causing intellectual disability and other serious health problems.

  4. Hyperphenylalaninemia - Wikipedia

    en.wikipedia.org/wiki/Hyperphenylalaninemia

    Phenylketonuria (PKU)-like symptoms, including more pronounced developmental defects, skin irritation, and vomiting, may appear when phenylalanine levels are near 20 mg/dL (1200 mol/L). [1] Hyperphenylalaninemia is a recessive hereditary metabolic disorder that is caused by the body's failure to convert phenylalanine to tyrosine as a result of ...

  5. 15 Most Common Puppy Health Issues and How to Spot Them - AOL

    www.aol.com/15-most-common-puppy-health...

    Related: Kennel Cough Symptoms and Ways to Help Your Dog Stay Comfortable Joint Abnormalities Patellar luxations, or knees that slip out of place when touched, are usually identified during the ...

  6. Tetrahydrobiopterin - Wikipedia

    en.wikipedia.org/wiki/Tetrahydrobiopterin

    Tetrahydrobiopterin (BH 4, THB), also known as sapropterin (INN), [5] [6] is a cofactor of the three aromatic amino acid hydroxylase enzymes, [7] used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the ...

  7. Aromatic amino acid - Wikipedia

    en.wikipedia.org/wiki/Aromatic_amino_acid

    Tyrosine is semi-essential; therefore, it can be synthesized by the animal, but only from phenylalanine. Phenylketonuria, a genetic disorder that occurs as a result of the inability to breakdown phenylalanine, is due to a lack of the enzyme phenylalanine hydroxylase. A dietary lack of tryptophan can cause stunted skeletal development. [9]

  8. Tyrosinemia type I - Wikipedia

    en.wikipedia.org/wiki/Tyrosinemia_type_I

    Patients received amino acid supplements lacking tyrosine and phenylalanine, most often by drinking a specially engineered formula, in order to acquire sufficient protein. It is recommended that tyrosine levels remain below 500 μmol/L. [5] Phenylalnine is the precursor to tyrosine. The ideology behind maintaining low tyrosine levels is two-fold.

  9. Skin conditions in dogs: Symptoms, causes, and how to help - AOL

    www.aol.com/skin-conditions-dogs-symptoms-causes...

    Dr. Rebecca MacMillan, a vet with over 15 years of experience, says she regularly sees four skin conditions in particular: skin allergies, parasites, acute moist dermatitis, and endocrine disease.

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