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Hormonal therapies to reduce or stop menstrual bleeding have long been used to manage a number of gynecologic conditions including menstrual cramps (dysmenorrhea), heavy menstrual bleeding, irregular or other abnormal uterine bleeding, menstrual-related mood changes (premenstrual syndrome or premenstrual dysphoric disorder), and pelvic pain due to endometriosis or uterine fibroids.
When a woman takes COCP, the hormones in the pills prevent both ovulation and shedding of the endometrium (menstruation). Traditionally, COCPs are packaged with 21 active (hormone-containing) pills and 7 placebo pills. During the week of placebo pills, withdrawal bleeding occurs and simulates an average 28-day menstrual cycle.
The hormones in the pill have also been used to treat other medical conditions, such as polycystic ovary syndrome (PCOS), endometriosis, adenomyosis, acne, hirsutism, amenorrhea, menstrual cramps, menstrual migraines, menorrhagia (excessive menstrual bleeding), menstruation-related or fibroid-related anemia and dysmenorrhea (painful menstruation).
Various formulations (10-50 μg estrogen (average 20–35) [16] and 0.05–3 mg progesterone [17]) 9% failure rate with typical use (method not used consistently or correctly) 0.3% failure rate with perfect use [7] [18] Meant to be taken at the same time every day (some pills can be taken within 2–24 hours and still be effective) [19]
MPA is an artificial progestogen, and as such activates the progesterone receptor, the biological target of progesterone. [4] It also has androgenic activity and weak glucocorticoid activity. Due to its progestogenic activity, MPA decreases the body's release of gonadotropins and can suppress sex hormone levels. [ 13 ]
“The easiest way to delay your period with birth control is to skip the placebo week and continue on the active pills,” she explains. Bleeding typically occurs during the placebo or sugar pill ...
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