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  2. Tumour heterogeneity - Wikipedia

    en.wikipedia.org/wiki/Tumour_heterogeneity

    Focused approach: analyzing a specific genetic locus or set of loci. This may occur through the detection of allelic imbalances (tumour DNA is compared to germline DNA), amplification of chromosomal regions , and/or sequencing specific genes. This method is used to trace the evolution of a specific mutation of interest, or to confirm a mutation ...

  3. Pan-cancer analysis - Wikipedia

    en.wikipedia.org/wiki/Pan-Cancer_Analysis

    Pan-cancer studies aim to detect the genes whose mutation is conducive to oncogenesis, as well as recurrent genomic events or aberrations between different tumors.For these studies, it is necessary to standardize the data between multiple platforms, establishing criteria between different researchers to work on the data and present the results.

  4. Carcinogenesis - Wikipedia

    en.wikipedia.org/wiki/Carcinogenesis

    The tumor types are typical for each type of tumor suppressor gene mutation, with some mutations causing particular cancers, and other mutations causing others. The mode of inheritance of mutant tumor suppressors is that an affected member inherits a defective copy from one parent, and a normal copy from the other.

  5. Cancer epigenetics - Wikipedia

    en.wikipedia.org/wiki/Cancer_epigenetics

    Most cases of lung cancer are because of genetic mutations in EGFR, KRAS, STK11 (also known as LKB1), TP53 (also known as p53), and CDKN2A (also known as p16 or INK4a) [117] [118] [119] with the most common type of lung cancer being an inactivation at p16. p16 is a tumor suppressor protein that occurs in mostly in humans the functional ...

  6. Somatic evolution in cancer - Wikipedia

    en.wikipedia.org/wiki/Somatic_evolution_in_cancer

    Cytogenetic studies localized the region to the long arm of chromosome 13, and molecular genetic studies demonstrated that tumorigenesis was associated with chromosomal mechanisms, such as mitotic recombination or non-disjunction, that could lead to homozygosity of the mutation. [22] The retinoblastoma gene was the first tumor suppressor gene ...

  7. Cancer - Wikipedia

    en.wikipedia.org/wiki/Cancer

    The classical view of cancer is a set of diseases driven by progressive genetic abnormalities that include mutations in tumor-suppressor genes and oncogenes, and in chromosomal abnormalities. A role for epigenetic alterations was identified in the early 21st century. [99]

  8. Oncogenomics - Wikipedia

    en.wikipedia.org/wiki/Oncogenomics

    Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.

  9. Peto's paradox - Wikipedia

    en.wikipedia.org/wiki/Peto's_paradox

    Peto's paradox is the observation that, at the species level, the incidence of cancer does not appear to correlate with the number of cells in an organism. [1] For example, the incidence of cancer in humans is much higher than the incidence of cancer in whales, [2] despite whales having more cells than humans.

  1. Related searches tumours form without genetic mutations in animals based on specific genes

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