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The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells. [ 1 ]
poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. Additionally, the WHO scheme recognizes mixed tumors with both neuroendocrine and epithelial carcinoma features, such as goblet cell cancer, a rare gastrointestinal tract tumor. [6]
Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
The two main types of hyperplastic polyps are microvesicular mucin-rich type and goblet cell-rich type. [1] A mucin-poor type with eosinophilic cytoplasm, which is rare, was previously described. [4] However, the mucin poor type is no longer considered a distinct subtype. [1]
Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. The growth pattern is distinctive: typically producing a concentric band of tumor nests interspersed among the muscle and stroma of the appendiceal wall extending up the shaft of the appendix. This makes the lesion ...
In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas . Signet ring cells are most frequently associated with stomach cancer , [ 1 ] but can arise from any number of tissues including the prostate , [ 2 ] bladder , gallbladder , [ 3 ] breast , colon , [ 4 ] ovarian stroma and ...
Bronchiolo-alveolar carcinoma, goblet cell type; M8254/3 Bronchiolo-alveolar carcinoma, mixed mucinous and non-mucinous (C34._) Bronchiolo-alveolar carcinoma, Club cell and goblet cell type; Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type; Bronchiolo-alveolar carcinoma, indeterminate type
(B) Squamous carcinoma: morphologically similar to other squamous cell carcinomas occurring in other organs with possible keratinization. (C) Clear cell carcinoma: clear cell cytoplasm identified in polygonal cells with a central nucleus, columnar cells with an eccentric nucleus (red arrow) and/or round/oval cells with abundant cytoplasm and ...