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The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells. [ 1 ]
Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
appendix, [19] including well differentiated NETs (benign); well differentiated NETs (uncertain malignant potential); well differentiated neuroendocrine carcinoma (with low malignant potential); mixed exocrine-neuroendocrine carcinoma (goblet cell carcinoma, also called adenocarcinoid and mucous adenocarcinoid) Hindgut GEP-NET [20] [21]
(a) Sometimes mucinous cells with voluminous cytoplasm can mimic goblet cells. Admixed lightly eosinophilic ciliated cells are almost always identifiable. (b) Background of prominent neutrophilic infiltration. Admixture of mucinous cells, eosinophilic cells, and some clear cells, with mild or moderate nuclear atypia and stratifications.
The two main types of hyperplastic polyps are microvesicular mucin-rich type and goblet cell-rich type. [1] A mucin-poor type with eosinophilic cytoplasm, which is rare, was previously described. [4] However, the mucin poor type is no longer considered a distinct subtype. [1]
A carcinoid (also carcinoid tumor) is a slow-growing [1] type of neuroendocrine tumor originating in the cells of the neuroendocrine system. In some cases, metastasis may occur. Carcinoid tumors of the midgut ( jejunum , ileum , appendix , and cecum ) are associated with carcinoid syndrome .
Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells: 21081128 [13] 19386267 [14] 8552090 [15] CTNNB1: Catenin, beta: Paneth cell differentiation. Essential for stem ...
ZG16 is a protein that is highly selective for cytoplasmic expression in mucin-producing goblet cells, [9] which are cells that are located in the gastrointestinal tract. These cells produce mucus to protect mucous membranes that line the surface of our internal organs. [10] The protein is mainly expressed in the human colon, endometrium, and ...