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Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [4] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol. [19] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.
The intracerebral route can also interrupt the blood brain barrier from holding up against subsequent routes. [19] Intracerebroventricular (into the cerebral ventricles) administration into the ventricular system of the brain. One use is as a last line of opioid treatment for terminal cancer patients with intractable cancer pain. [20]
Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia , ileus , or bowel obstruction , that would interfere with the progression of the medication through the tract.
The Macy Catheter is a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal route. The catheter was developed to make rectal access more practical and provide a way to deliver and retain liquid formulations in the distal rectum so that health practitioners can leverage the established benefits of rectal administration.
A Murphy drip apparatus [1]. A Murphy drip is a rectal infusion apparatus to administer the medical procedure of proctoclysis, also known as rectoclysis. [2] [3] During the procedure, an end of the Murphy drip is inserted into the rectum and large quantities of liquid are infused into the rectum drop by drop. [4]
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[1] [2] [29] However, one study of 13 patients with hepatorenal syndrome showed significant improvement in kidney function when the two were used together (with midodrine given orally, octreotide given subcutaneously and both dosed according to blood pressure), with three patients surviving to discharge. [30]
An alcohol enema, also known colloquially as butt-chugging or boofing, is the act of introducing alcohol into the rectum and colon via the anus, i.e., as an enema.This method of alcohol consumption can be dangerous and even deadly because it leads to faster intoxication than drinking since the alcohol is absorbed directly into the bloodstream and bypasses the body's ability to reject the toxin ...
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