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  2. Benadryl challenge - Wikipedia

    en.wikipedia.org/wiki/Benadryl_challenge

    The recommended dosage of Benadryl tablets for adults is 1 to 2 tablets every 4 to 6 hours, [1] and only 1 tablet every 4 to 6 hours for children under the age of 12. [2]The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States ...

  3. Benadryl for Dogs? A Vet Explains How Much You Should Give - AOL

    www.aol.com/benadryl-dogs-vet-explains-much...

    Benadryl Doses by Use. The normal dose of Benadryl varies somewhat depending on what it is being used for: Allergies. The normal dose for allergies is 1–2 mg per pound of body weight up to every ...

  4. Diphenhydramine - Wikipedia

    en.wikipedia.org/wiki/Diphenhydramine

    Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. [47]

  5. What is the Benadryl challenge? Why the FDA, TikTok ... - AOL

    www.aol.com/lifestyle/what-is-the-benadryl...

    Multiple teens have been hospitalized after ingesting up to 14 Benadryl doses at once, inspired by a TikTok challenge aimed at hallucinating. Experts say the activity could be deadly.

  6. ‘Benadryl’ TikTok challenge may have caused the death of an ...

    www.aol.com/benadryl-tiktok-challenge-may-caused...

    One of the latest trends sweeping across TikTok, which involves taking an excessive amount of Benadryl, may have caused the death of a 15-year-old girl from Oklahoma. The dangerous online ...

  7. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1] The related terms therapeutic window or safety window refer to a range of doses optimized between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or ...

  8. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.

  9. Oklahoma student Nex Benedict’s cause of death revealed - AOL

    www.aol.com/oklahoma-student-nex-benedict-cause...

    Diphenhydramine and Fluoxetine are commonly known as Benadryl and Prozac. Oklahoma student Nex Benedict’s cause of death revealed (AP) The teenager was beaten by other students inside a school ...